QconCAT Kit – cardiovascular diseases

QconCAT Kit for detection and absolute quantification of biomarkers linked to cardiovascular diseases in human, mouse and rat samples.

Order Number Size Labelling Price
PQ-CVD-Kit 200 applications 15N € 2.500,-

PolyQuant’s CVD Kit provides 211 reference peptides for absolute protein quantification of 47 plasma proteins linked to cardiovascular diseases and is designed for application in human, mouse and rat samples, by using peptides that are shared between all three organisms. The peptides are grouped according to plasma protein expression levels onto four individual QconCAT proteins.

The protein panel includes biomarker proteins enabling the determination of the risk for developing cardiovascular diseases, but can also be adapted for other diseases. It can be easily combined with additional standards for other proteins of interest.

Other labelling options are available upon request.

PolyQuant has established routine protocols for targeted LC-MS/MS measurement of the kit’s peptides. Contact us for sample preparation and measurement service at low cost.

Contains:

Component Description
PQ-CVD-1 QconCAT for high abundant proteins
PQ-CVD-2 QconCAT for medium abundant proteins
PQ-CVD-3 QconCAT for low abundant proteins
PQ-CVD-4 QconCAT for low abundant proteins
RePLiCal Calibration standard for retention time normalization

Use case:

Targeted LC-MS/MS for the evaluation of proteomics biomarkers in the blood of neonates with necrotizing enterocolitis and late-onset sepsis

Analytical and Bioanalytical Chemistry 2018

Chatziioannou et al. used a subset of PolyQuant’s CVD kit and some additional proteins of interest. They were able to define two panels of three proteins each that allow highly sensitive diagnosis of late-onset sepsis (LOS) and differential diagnosis between LOS and necrotizing enterocolitis.

Order Information

To place your order, please contact us directly through:

E-Mail

Phone: +49 (0)9405 96999 10

Or Fax: +49 (0)9405 96999 28

Product Information

The CVD-Kit comprises of 4 QconCAT polypeptides covering 47 proteins with 211 peptides and is based on quantitative proteomics results of the TransCard project, a multidisciplinary research consortium of two SMEs and four academic partners studying the molecular origin of disturbed LDL, triglyceride and/or HDL metabolism, correlated with cardiovascular disease (CVD).

By selecting peptides that are shared between human, mouse and rat, the kit can be applied in studies empolying any of these prominent model organisms for CVD research.

The Kit contains 4 heavy isotope labelled QconCAT proteins for 200 applications and the RePLiCal calibration standard for retention time normalization. The QconCAT proteins can be used individually, as mix or in combination with other reference standards.

Protein list:
PQ-CVD-1PQ-CVD-2PQ-CVD-3PQ-CVD-4
APOA1APOC4MMP9LPL
APOBAPOC1ADAM17LIPC
CLUAPOMEXT1LIPG
APODCRPEXT2ANGPTL2
PZPAPOL1NDST1ANGPTL3
A2MAPOFNDST2ANGPTL4
APOA2LCATSULF1ANGPTL8
APOEADIPOQSULF2LDLR
RBP4APOC2SDC1LRP1
APOC3PLTPGPD1SCARB1
APOA4CETPPCSK9
LBPAPOA5
LPA
HSPA5

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Our prices are net prices, i.e. they do not contain value added taxes or customs fees. These taxes have to be paid by the customer.
Shipment costs depend on destination and packaging (either on dry ice or ambient temperature shipping).

For questions please contact us.

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