The purpose of discovery proteomics is to gather information about all proteins and protein forms in a biological sample. With only little previous knowlegde of the sample, discovery proteomics can identify thousands of proteins and protein forms in a single experiment. Sample fractionation allows for even deeper screening of your samples. Thus, discovery proteomics is typically the first step in any larger proteomics project.
On top of protein identification, discovery proteomics also allows for relative protein quantification, i.e. comparing protein abundances in different samples.
Employing mass spectrometry for discovery proteomics has many advantages:
- High sensitivity
- Unbiased approach
- no complex sample preparation needed
Application areas include expression profiling, host cell protein analysis, identification of chemical modifications, biomarker research, drug target discovery, mode of action studies, pathway modeling, and many more.
For more information, assistance and support in planning and execution of your proteomics project you can contact us: