Drug discovery and toxicity

 

The main focus of pharmacology research is an identification of molecules that are potentially effective for disease treatment and have less harmful effect on normal physiology. Biomarkers identified with the help of proteomics are used for drug discovery, as far as proteins appear to be the main drug targets.

 

 

Up to hundred proteins are involved in different pathways in normal and malignant physiology.  Numerous screenings are done in vitro and on the experimental animal models to identify the efficacy or toxicity of potential drug candidates. Multiplex assays are an essential tool to demonstrate a quantitative correlation between drug action and pathological event. Investigation for drug–response or drug-induced toxicity is performed on samples from different species and is usually measured in kidney, liver, heart and nervous system.

QconCAT technology corresponds to protein assay requirements in drug discovery and toxicology

  • Multiplexing of up to 100 proteins
  • Absolute quantification
  • Highly sensitive
  • Antibody-free
  • Cost-efficient
  • Highly reproducible
  • Small sample volume
  • Applicable to sample of any nature (blood, urine, CSF, tissue sample, etc)
  • Applicable to samples of different species (human, rat, mouse, etc)

QconCAT technology is a powerful tool to study potential drug effects on proteome, investigate and validate toxicity biomarkers. According to your needs you can choose from our drug discovery and toxicity related products and services.

QconCAT products
Ready toxicology kits

for protein quantification, composed of control isotope labeled protein mixtures for mass spectrometry analysis

  • Nephrotoxicity
  • Hepatotoxicity
  • Cardiotoxicity
  • Neurotoxicity

We invite area experts to suggest toxicity related biomarker panels that could serve as inter laboratory controls and will allow creating available off-shelf kits for fast and reproducible protein quantification

Customized assays

We will create a quantification kit based on your proposed protein list

QconCAT full service

If you are not equipped to perform mass spectrometry or if you want to save time and resources, we offer a full service where we create the QconCAT and perform the protein quantification of your samples in-house.

 

Contact our experts for more details and get professional advice on your protein quantification assay